| Date | Location | Result | |
| Dec 04, 2021 | Bozeman, Mont. | Montana State 26, UT Martin 7 | Box score |
| Nov 27, 2021 | Springfield, Mo. | UT Martin 32, Missouri State 31 | Box score |
| Nov 20, 2021 | Clarksville, Tenn. | Austin Peay 48, Tennessee Tech 20 | Box score |
| Nov 20, 2021 | Starkville, Miss. | Mississippi State 55, Tennessee State 10 | Box score |
| Nov 20, 2021 | Cape Girardeau, Mo. | Southeast Missouri 31, UT Martin 14 | Box score |
| Nov 20, 2021 | Charleston, Ill. | Murray State 20, Eastern Illinois 13 | Box score |
| Nov 13, 2021 | Murray, Ky. | Murray State 28, Southeast Missouri 10 | Box score |
| Nov 13, 2021 | Nashville, Tenn. | Austin Peay 36, Tennessee State 7 | Box score |
| Nov 13, 2021 | Cookeville, Tenn. | UT Martin 42, Tennessee Tech 3 | Box score |
| Nov 06, 2021 | Murray, Ky. | Murray State 32, Tennessee Tech 27 | Box score |
| Nov 06, 2021 | Martin, Tenn. | UT Martin 41, Tennessee State 20 | Box score |
| Nov 06, 2021 | Clarksville, Tenn. | Austin Peay 42, Eastern Illinois 26 | Box score |
| Oct 30, 2021 | Nashville, Tenn. | Tennessee State 27, Murray State 21 | Box score |
| Oct 30, 2021 | Cape Girardeau, Mo. | Southeast Missouri 38, Eastern Illinois 15 | Box score |
| Oct 30, 2021 | Martin, Tenn. | UT Martin 17, Austin Peay 16 | Box score |
| Oct 23, 2021 | Murray, Ky. | Austin Peay 47, Murray State 6 | Box score |
| Oct 23, 2021 | Martin, Tenn. | UT Martin 38, Southeast Missouri 30 | Box score |
| Oct 23, 2021 | Cookeville, Tenn. | Tennessee Tech 56, Virginia-Lynchburg 13 | Box score |
| Oct 23, 2021 | Charleston, Ill. | Tennessee State 28, Eastern Illinois 0 | Box score |
| Oct 16, 2021 | Nashville, Tenn. | Tennessee State 20, Tennessee Tech 13 | Box score |
| Oct 16, 2021 | Cape Girardeau, Mo. | Murray State 32, Southeast Missouri 31 | Box score |
| Oct 16, 2021 | Charleston, Ill. | UT Martin 28, Eastern Illinois 17 | Box score |
| Oct 09, 2021 | Durham, N.C. | Tennessee Tech 27, N.C. Central 16 | Box score |
| Oct 09, 2021 | Clarksville, Tenn. | Southeast Missouri 30, Austin Peay 14 | Box score |
| Oct 09, 2021 | Martin, Tenn. | UT Martin 48, Murray State 24 | Box score |
| Oct 02, 2021 | Clarksville, Tenn. | Tennessee State 24, Austin Peay 22 | Box score |
| Oct 02, 2021 | Murray, Ky. | Murray State 22, Eastern Illinois 6 | Box score |
| Oct 02, 2021 | Cookeville, Tenn. | Tennessee Tech 28, Southeast Missouri 17 | Box score |
| Sep 25, 2021 | Richmond, Ky. | Eastern Kentucky 35, Austin Peay 27 | Box score |
| Sep 25, 2021 | Cape Girardeau, Mo. | Southeast Missouri 47, Tennessee State 14 | Box score |
| Sep 25, 2021 | Jacksonville, Ala. | UT Martin 34, Jacksonville State 31 | Box score |
| Sep 25, 2021 | Cookeville, Tenn. | Eastern Illinois 28, Tennessee Tech 14 | Box score |
| Sep 18, 2021 | Charleston, Ill. | Illinois State 31, Eastern Illinois 24 | Box score |
| Sep 18, 2021 | Bowling Green, Ohio | Bowling Green 27, Murray State 10 | Box score |
| Sep 18, 2021 | Natchitoches, La. | UT Martin 35, Northwestern State 10 | Box score |
| Sep 18, 2021 | Nashville, Tenn. | Tennessee State 41, Kentucky State 7 | Box score |
| Sep 18, 2021 | Clarksville, Tenn. | Austin Peay 59, Morehead State 35 | Box score |
| Sep 18, 2021 | Columbia, Mo. | Missouri 59, Southeast Missouri 28 | Box score |
| Sep 18, 2021 | Knoxville, Tenn. | Tennessee 56, Tennessee Tech 0 | Box score |
| Sep 11, 2021 | Oxford, Miss. | Ole Miss 54, Austin Peay 17 | Box score |
| Sep 11, 2021 | Huntsville, Texas | Sam Houston 52, Southeast Missouri 14 | Box score |
| Sep 11, 2021 | Martin, Tenn. | UT Martin 33, Samford 27 | Box score |
| Sep 11, 2021 | Memphis, Tenn. | Jackson State 38, Tennessee State 16 | Box score |
| Sep 11, 2021 | Cincinnati, Ohio | Cincinnati 42, Murray State 7 | Box score |
| Sep 11, 2021 | Dayton, Ohio | Dayton 17, Eastern Illinois 10 | Box score |
| Sep 11, 2021 | Cookeville, Tenn. | Furman 26, Tennessee Tech 0 | Box score |
| Sep 05, 2021 | Canton, Ohio | Grambling 16, Tennessee State 10 | Box score |
| Sep 04, 2021 | Columbia, S.C. | South Carolina 46, Eastern Illinois 0 | Box score |
| Sep 02, 2021 | Chattanooga, Tenn. | Austin Peay 30, Chattanooga 20 | Box score |
| Sep 02, 2021 | Bowling Green, Ky. | Western Kentucky 59, UT Martin 21 | Box score |
| Sep 02, 2021 | Cape Girardeau, Mo. | Southern Illinois 47, Southeast Missouri 21 | Box score |
| Sep 02, 2021 | Murray, Ky. | Murray State 35, Miss. Valley State 0 | Box score |
| Sep 02, 2021 | Birmingham, Ala. | Samford 52, Tennessee Tech 14 | Box score |
| Aug 28, 2021 | Terre Haute, Ind. | Indiana State 26, Eastern Illinois 21 | Box score |